Since this question came up again today, I figure it was worth sharing in case others also had trouble using the vSphere Guest Operations API in VMware Cloud on AWS (VMC), which includes PowerCLI's Invoke-VMScript and Copy-VMGuestFile cmdlet. There are a couple of requirements that you must satisfy both in the GuestOS as well as between your on-prem vSphere environment and VMC.
- VMware Tools installed and running, it may seem obvious, but I have had customers trying to use various scripts without realizing this was a requirement. You should also ensure that you are running the latest version of VMware Tools, especially as there bugfixes that may impact Guest Operations APIs.
- VPN or Direct Connect (DX) configured between your on-prem vSphere environment and VMC, this is required as you will need access to ESXi hosts which is only available through a VPN or DX
- Create a VMC firewall rule to allow access from your on-prem network to VMC's ESXi hosts on port 443 which is used for Guest Operations access including transferring files to and from the GuestOS
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The VMC firewall rule is usually the thing that most folks forget about and this simply because for most on-prem environment, access to ESXi over 443 is just sort of a default.
Once you have configured the VMC firewall to allow 443 to ESXi hosts, you will be able to use the Guest Operations API including Invoke-VMScript and Copy-VMGuestFile to a VM running in VMC

Very nice blog thanks for share.