vSphere Lifecycle Manager (vLCM) allows users to upload an ESXi component into its depot using the Import Updates operation in the vSphere UI, but deleting an ESXi component from the vLCM depot is currently not possible when using the vSphere UI.
However, using the vLCM REST API we can delete an ESXi component from the vLCM depot with the Settings Depots Offline APIs. To demonstrate these specific vLCM REST APIs, I will be using PowerCLI (Connect-CisServer) but you can also use the vLCM REST API directly via any REST Client.