When using the popular vCenter Converter tool for performing a Physical-to-Virtual (P2V) or Virtual-to-Virtual (V2V) migration of Microsoft Windows, the MachineGuid (HKLM->SOFTWARE->Microsoft->Cryptography->MachineGuid) can change based on your migration settings.
By default, the Reconfigure destination virtual machine option is selected to help ensure the converted virtual machine will properly start in the destination environment as outlined in the vCenter Converter documentation.